Twentyone Hotel

Via Cola Di Rienzo 23, Vaticano Prati, Rome, Italy - Close to major attractions
4.0/5
· 1904 reviews

The 4-star Twentyone Hotel Rome is located in the Via Cola di Rienzo district of Rome, about 5 minutes' walk from Tevere. Featuring 88 rooms with views of the sea, the hotel is 1.3 miles from the large sunny square "Piazza Venezia".

Location

Located approximately 10 minutes' drive from Colosseum Arena, this Rome hotel is also around 25 minutes by foot from the aqueduct-fed rococo Trevi Fountain. Sports fans can also visit Stadio Olimpico Stadium, 1.9 miles from the Twentyone, and take their families to the 17-hectare zoological garden "Bioparco di Roma", which is 1.4 miles away. Guests will also appreciate the vicinity to Giardino di Palazzo Borghese, located merely 12 minutes' walk away. Not far from this property there is the minor basilica "Church of Santa Maria del Popolo". Lepanto subway station is 0.2 miles from the Twentyone Rome and Flaminio city rail is 0.4 miles away.

Rooms

All of the allergy-free rooms are appointed with a flat-screen TV with satellite channels along with a mini fridge bar and coffee/tea making equipment, and some of them include a balcony and a seating area. Bathroom facilities include a bidet, a separate toilet, and a shower, as well as comforts such as hair dryers and shower caps.

Food & Drinks

Le Sicilianedde is situated just around the corner from the Twentyone.

Why choose Twentyone Hotel Rome

Select room
  • Strategic location near Vatican

  • Modern and elegant rooms

  • On-site Bistro 21 restaurant

  • 24-hour reception services

Main amenities

  • Wi-Fi

  • 24-hour services

  • Express check-in/ -out

  • Fitness/Gym

  • On-site Dining

  • No Smoking

  • Child-friendly

  • Wheelchair access

  • Breakfast

  • Air conditioning

  • No pets allowed

General
  • Wi-Fi
  • 24-hour services
  • Express check-in/ -out
  • Fitness/Gym
  • On-site Dining
  • No Smoking
  • Child-friendly
  • Wheelchair access
  • Breakfast
  • Air conditioning
  • No pets allowed
1/30

Internet

  • Wi-Fi

Parking options

  • Parking

Shuttle

  • Paid airport shuttle

Activities

  • Fitness centre

Property services

  • Safe deposit box
  • 24-hour reception
  • Express check-in/ -out
  • Security
  • Luggage storage
  • Barber shop
  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Tours/Ticket assistance
  • Welcome drink

Dining options

  • In-room breakfast
  • Restaurant
  • Snack bar
  • Bar/ Lounge area
  • Packed lunches
  • Special diet menus

Business facilities

  • Fax/Photocopying

For kids

  • Cots
  • Children's buffet

Recreation

  • Garden area
  • Leisure/ TV room

For disabled guests

  • Rooms/ Facilities for disabled
  • Wheelchair access
  • Toilet for disabled
  • Bathroom for disabled

In the rooms

  • Air conditioning
  • Heating
  • Mini-bar
  • Soundproofed rooms
  • Sitting area
  • Terrace
  • Garden furniture
  • Tea and coffee facilities
  • Ironing facilities

In the bathroom

  • Free toiletries
  • Sink

Devices

  • Flat-screen TV
  • AM/FM alarm clock

Design

  • Carpeted floor

General facilities

  • Non-smoking rooms
  • Allergy-free rooms
  • Lift
  • Coffee shop
  • Smoke detectors
  • Electric vehicle charging station
  • Fire extinguishers
  • Key card access

Pets

  • No pets allowed

Important information

Check-in:
from 15:00 until 23:59
Check-out:
from 07:00 until 11:00
License number058091-ALB-00313,IT058091A1GZ5MCI9I
  • Children and extra beds
  • There are no cribs provided in a room.

Enter dates to see availability

From USD 82 per night
Check-in 16 May 2026
Check-out 17 May 2026
Guests 2 guests

Adults:

2

Children:

0
All rates verified
How we verified prices Our team regularly checks prices to make sure you see the lowest available rates. We compare them with hotel prices and other providers. If discounts or promotions appear, prices on our site are updated accordingly.

Rooms

Photos of Twentyone Hotel Rome

Location of Twentyone Hotel Rome

Via Cola Di Rienzo 23, Vaticano Prati, Rome, Italy

 -  Close to major attractions
Attractions
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    100% Verified Reviews
    Enter dates to see availability
    From USD 82 per night
    Check-in 16 May 2026
    Check-out 17 May 2026
    Guests 2 guests

    Adults:

    2

    Children:

    0
    All rates verified
    How we verified prices Our team regularly checks prices to make sure you see the lowest available rates. We compare them with hotel prices and other providers. If discounts or promotions appear, prices on our site are updated accordingly.
    Check-in & out
    16 May 2026
    17 May 2026
    Guests
    2 guests
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    Important information
    Twentyone Hotel
    Check-in:
    from 15:00 until 23:59
    Check-out:
    from 07:00 until 11:00
    License number058091-ALB-00313,IT058091A1GZ5MCI9I
    • Children and extra beds
    • There are no cribs provided in a room.